Turkish Economy Minister Zafer Caglayan and Interior Minister Muammer Guler have resigned after their sons were charged amid a corruption inquiry that has hit the government.
Twenty-four people have been charged as part of the investigation, including the head of state-owned Halkbank.
In a statement, Mr Caglayan condemned the inquiry as an "ignoble operation".
PM Recep Tayyip Erdogan has threatened to "break the hands" of rivals who used the inquiry to undermine his rule.
Mr Caglayan's son Kaan and Baris Guler, the interior minister's son, have both denied accusations of involvement in bribery relating to urban development projects and the allocation of construction permits.
The economy minister, in his statement, said he was stepping down "so that all the light may be laid on this ignoble operation that targets our government".
In response to the police crackdown, a number of police commissioners have been removed from their posts, including the head of police in Istanbul.