At least 23 people were killed across Gaza, Palestinian officials said on Wednesday, by a bombardment Israel said may be just the start of a lengthy offensive against Islamist militants whose rockets struck deeper than ever before into Israel.
Israelis ran for cover late on Tuesday as air-raid sirens sounded in the business capital Tel Aviv and the holy city of Jerusalem, both of which were hit in the Gaza war of November 2012.
Hamas said it also fired a rocket at the major northern city of Haifa, 140 km (88 miles) away, and though this was not confirmed, Israel said a rocket had landed in Hadera, 100 km (60 miles) from Gaza, further than had previously been reached.
While the Israelis reported no casualties, the long-range salvo was celebrated by the outgunned Palestinians as proof of their resolve in hostilities that flared three weeks ago after the abduction and murder of three Jewish seminary students.
The rocket strikes could lead to an Israeli ground invasion, something officials have said is a possible option.
In the densely populated Gaza Strip, explosions echoed day and night, shaking buildings and sending up plumes of smoke. At least 17 civilians, including five children, were among the 23 dead, Palestinian officials said. On the Israeli side, at least two people were wounded, medics said.
Israel assassinated a senior local leader of the Islamic Jihad militant group in the northern Gaza Strip early on Wednesday, neighbours and hospital officials said, and five others including family members were killed.
An Israeli military spokeswoman said she had no initial details on the strike.
The militant, Hafez Hamad, two brothers and his parents were killed when his house was bombed in an air strike in the town of Beit Hanoun in the northern Gaza Strip, Hamas media and Gaza interior ministry said. An unidentified woman in the house was also killed.
Another Hamas militant was targeted in another air strike in Rafah, in the southern Gaza Strip, Hamas officials said.
Since Israel launched its offensive on Tuesday, five Hamas gunmen, an Islamic Jihad leader and 17 civilians, including seven children, have been killed.
On Tuesday afternoon, Israel's Iron Dome interceptor shot down a rocket fired at Tel Aviv by Gaza faction Islamic Jihad.
"We will not tolerate rocket fire against our cities and townships, and therefore I ordered a significant broadening of IDF (Israel Defence Force) operations against the terrorists of Hamas and other terror groups in the Gaza Strip," Prime Minister Benjamin Netanyahu said in a statement.
He called on Israelis to rally together and "show resilience because this operation could take time".
Israel has threatened to invade Gaza if the rockets persist.
In a bold infiltration, gunmen from Hamas landed on the shore near Zikim adjacent to the Gaza border, where a kibbutz and a military base are located. Four gunmen were killed.